On-site manipulation of single chromosomal DNA molecules by using optically driven microstructures

Kyohei Terao; Masao Washizu; Hidehiro Oana

doi:10.1039/B803753A

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Lab on a Chip

Issue 8, 2008

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On-site manipulation of single chromosomal DNA molecules by using optically driven microstructures

Kyohei Terao , Masao Washizu and Hidehiro Oana

Lab Chip, 2008, 8, 1280-1284

DOI: 10.1039/B803753A
Received 06 Mar 2008, Accepted 19 May 2008
First published on the web 23 Jun 2008

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Abstract
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We report a novel method for manipulation of single giant DNA molecules under a video microscope. Using optically driven microstructures, we manipulated chromosomal DNA of length in the order of millimetres, extended by electroosmotic flow without DNA breakage in aqueous solution: we picked up DNA, using microfabricated hooks and wound it around microfabricated bobbins.

Supplementary Info

Movie of manipulation with a microhook
MOV (1131K)
Movie of winding of DNA
MOV (1498K)
Movie of unwinding of DNA
MOV (9738K)

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