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Issue 5, 2008
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All-terrain droplet actuation

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Digital microfluidics has become a popular tool for biochemical and biomedical applications. However, its current format is restricted to actuation of droplets on a single plane. Here, we introduce a new method for fluid handling on flexible devices, which we have termed all-terrain droplet actuation (ATDA). We show that ATDA can be used to manipulate droplets across a wide range of geometries, including inclined, declined, vertical, twisted, and upside-down architectures. These new geometries enable flexible, straightforward integration of distinct physicochemical environments on monolithic devices. To illustrate this capacity, we developed temperature- and oxygen-sensitive colorimetric sensors, as well as an automated method for selective enrichment of DNA from a heterogeneous mixture. We anticipate that ATDA will be a useful new tool in the growing trend toward laboratory miniaturization.

Graphical abstract: All-terrain droplet actuation

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The article was received on 28 Jan 2008, accepted on 12 Mar 2008 and first published on 02 Apr 2008

Article type: Paper
DOI: 10.1039/B801516C
Citation: Lab Chip, 2008,8, 672-677
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    All-terrain droplet actuation

    M. Abdelgawad, S. L. S. Freire, H. Yang and A. R. Wheeler, Lab Chip, 2008, 8, 672
    DOI: 10.1039/B801516C

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