Nano-biopower supplies for biomolecular motors: the use of metabolic pathway-based fuel generating systems in microfluidic devices

Joshua R. Wasylycia; Svetlana Sapelnikova; Hyuk Jeong; Jelena Dragoljic; Sandra L. Marcus; D. Jed Harrison

doi:10.1039/B801033A

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Lab on a Chip

Issue 6, 2008

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Nano-biopower supplies for biomolecular motors: the use of metabolic pathway-based fuel generating systems in microfluidic devices

Joshua R. Wasylycia , Svetlana Sapelnikova , Hyuk Jeong , Jelena Dragoljic , Sandra L. Marcus and D. Jed Harrison

Lab Chip, 2008, 8, 979-982

DOI: 10.1039/B801033A
Received 21 Jan 2008, Accepted 12 Mar 2008
First published on the web 11 Apr 2008

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We report fuel generation systems for molecular motors based on pyruvate kinase, or for the first time, mitochondria, implemented within microfluidic devices. Intact organelles acted as bio-nanopower supplies for molecular motors, using isolated mitochondria to convert chemical energy from succinate to ATP, harnessing nature's enzymatic transformation cascades directly. Motors were activated essentially equally by ATP produced by pyruvate kinase, mitochondria, or direct addition of ATP.

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Movie showing motility of microtubules
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Joshua R. Wasylycia
Svetlana Sapelnikova
Hyuk Jeong
Jelena Dragoljic
Sandra L. Marcus
D. Jed Harrison

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Nano-biopower supplies for biomolecular motors: the use of metabolic pathway-based fuel generating systems in microfluidic devices

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