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Issue 6, 2008
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Protecting, patterning, and scaffolding supported lipid membranes using carbohydrate glasses

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Abstract

Disaccharides are known to protect sensitive biomolecules against stresses caused by dehydration, both in vivo and in vitro. Here we demonstrate how interfacial accumulation of trehalose can be used to (1) produce rugged supported lipid bilayers capable of near total dehydration; (2) enable spatial patterning of membrane micro-arrays; and (3) form stable bilayers on otherwise lipophobic substrates (e.g., metal transducers) thus affording protecting, patterning, and scaffolding of lipid bilayers.

Graphical abstract: Protecting, patterning, and scaffolding supported lipid membranes using carbohydrate glasses

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Publication details

The article was received on 10 Jan 2008, accepted on 13 Mar 2008 and first published on 11 Apr 2008


Article type: Paper
DOI: 10.1039/B800370J
Citation: Lab Chip, 2008,8, 892-897
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    Protecting, patterning, and scaffolding supported lipid membranes using carbohydrate glasses

    A. E. Oliver, E. L. Kendall, M. C. Howland, B. Sanii, A. P. Shreve and A. N. Parikh, Lab Chip, 2008, 8, 892
    DOI: 10.1039/B800370J

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