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Issue 6, 2008
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Rapid microfabrication of solvent-resistant biocompatible microfluidic devices

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Abstract

This paper presents a rapid, simple, and low-cost fabrication method to prepare solvent resistant and biocompatible microfluidic devices with three-dimensional geometries. The devices were fabricated in thiolene and replicated from PDMS master with high molding fidelity. Good chemical compatibility for organic solvents allows volatile chemicals in synthesis and analysis applications. The surface can be processed to be hydrophobic or hydrophilic for water-in-oil and oil-in-water emulsions. Monodisperse organic solvent droplet generation is demonstrated to be reproducible in thiolene microchannels without swelling. The thiolene surface prevents cell adhesion but normal cell growth and adhesion on glass substrates is not affected by the adjacent thiolene patterns.

Graphical abstract: Rapid microfabrication of solvent-resistant biocompatible microfluidic devices

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Publication details

The article was received on 15 Nov 2007, accepted on 11 Mar 2008 and first published on 08 Apr 2008


Article type: Technical Note
DOI: 10.1039/B717710K
Citation: Lab Chip, 2008,8, 983-987
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    Rapid microfabrication of solvent-resistant biocompatible microfluidic devices

    L. Hung, R. Lin and A. P. Lee, Lab Chip, 2008, 8, 983
    DOI: 10.1039/B717710K

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