Issue 1, 2008
From the journal:

Lab on a Chip

Demonstration of a bio-microactuator powered by vascular smooth muscle cells coupled to polymer micropillars

Yo Tanaka,ab   Kae Sato,c   Tatsuya Shimizu,bd   Masayuki Yamato,bd   Teruo Okano,bd   Ichiro Manabe,e   Ryozo Nagaie  and  Takehiko Kitamori*abc  

* Corresponding authors

a Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: kitamori@icl.t.u-tokyo.ac.jp
Fax: +81 3-5841-6039
Tel: +81 3-5841-7231

b Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Kawaguchi, Saitama, Japan

c Center for NanoBio Integration, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

d Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, Japan

e Department of Cardiovascular Medicine and Molecular Pathology, School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

Abstract

We have demonstrated the working principle of a bio-microactuator using smooth muscle cells (SMCs) by driving micropillars coupled to cultured SMCs and controlled pillar displacements by chemical stimuli; the generated driving force was estimated to be over 1.1 µN.

Graphical abstract: Demonstration of a bio-microactuator powered by vascular smooth muscle cells coupled to polymer micropillars

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Article information

DOI
https://doi.org/10.1039/B714252H
Article type
Communication
Submitted
14 Sep 2007
Accepted
15 Nov 2007
First published
22 Nov 2007

Lab Chip, 2008,8, 58-61

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Demonstration of a bio-microactuator powered by vascular smooth muscle cells coupled to polymer micropillars

Y. Tanaka, K. Sato, T. Shimizu, M. Yamato, T. Okano, I. Manabe, R. Nagai and T. Kitamori, Lab Chip, 2008, 8, 58 DOI: 10.1039/B714252H

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