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Issue 2, 2008
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Electrokinetic microfluidic devices for rapid, low power drug delivery in autonomous microsystems

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Abstract

In this work, a low power and robust electroactive microwell-based implantable drug delivery system, intended for use with autonomous microsystems, is presented. The device comprises of an upper silicon based structure in which the drug storage sites are defined and a lower electrically functionalized PDMS (polydimethylsiloxane) backing. The drug ejection mechanism developed here exploits localized electrokinetic effects to control both the release time and release rate of chemicals stored in independent well sites. It is shown how this can reduce the dosage time from hours to seconds over previous diffusion based approaches, using as little as 20 mJ of energy per dose. This paper focuses on presenting the design and characterizing the electrokinetic transport mechanics which govern the release time and dispersal pattern of the well contents using a series of experimental and numerical techniques.

Graphical abstract: Electrokinetic microfluidic devices for rapid, low power drug delivery in autonomous microsystems

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Publication details

The article was received on 30 Aug 2007, accepted on 29 Nov 2007 and first published on 14 Dec 2007


Article type: Paper
DOI: 10.1039/B713325A
Citation: Lab Chip, 2008,8, 330-338
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    Electrokinetic microfluidic devices for rapid, low power drug delivery in autonomous microsystems

    A. J. Chung, D. Kim and D. Erickson, Lab Chip, 2008, 8, 330
    DOI: 10.1039/B713325A

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