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Issue 30, 2008
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Galvanic coupling conducting polymers to biodegradable Mg initiates autonomously powered drug release

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Abstract

Electrical stimulation to affect localised and controlled release of therapeutic drugs is becoming an attractive option in the treatment of acute diseases or chronic illnesses. Currently the materials developed for this technique rely on power sources to operate, making their progression from the laboratory to the biomedical marketplace problematic. To help alleviate this issue, we have demonstrated autonomously powered controlled release of a drug by exploiting the galvanic couple between biodegradable Mg alloy and a conducting organic polymer. We also demonstrate the ability to control the rate of drug release by utilizing a range of biodegradable polymer coatings on the Mg alloy. Combination of the biodegradable Mg and conducting polymer provides a biocompatible platform for the autonomously controlled release of a drug at therapeutic levels.

Graphical abstract: Galvanic coupling conducting polymers to biodegradable Mg initiates autonomously powered drug release

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Publication details

The article was received on 01 Apr 2008, accepted on 28 May 2008 and first published on 02 Jul 2008


Article type: Paper
DOI: 10.1039/B805481A
Citation: J. Mater. Chem., 2008,18, 3608-3613
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    Galvanic coupling conducting polymers to biodegradable Mg initiates autonomously powered drug release

    S. E. Moulton, M. D. Imisides, R. L. Shepherd and G. G. Wallace, J. Mater. Chem., 2008, 18, 3608
    DOI: 10.1039/B805481A

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