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Issue 30, 2008
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Structural characterization of sol–gel derived Sr-substituted calcium phosphates with anti-osteoporotic and anti-inflammatory properties

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Abstract

Sol–gel chemistry has been successfully used to prepare un-doped and Sr-doped calcium phosphate ceramics exhibiting a porous structure. The samples composition is very close to the nominal one. All samples present phase mixtures of mainly hydroxyapatite (HAp) and tricalcium phosphate (β-TCP). Doping with Sr2+ ions has a clear effect on the proportions of the different phases, increasing the amount of β-TCP. An amorphous phase is also observed incorporating some 40% of the total amount of strontium. Strontium ions also substitute for calcium both in HAp and β-TCP in specific sites that have been determined from Rietveld refinement on synchrotron powder diffraction data. The soluble amorphous and TCP phases are responsible for a beneficial partial release of strontium ions in solution during interactions between the material and biological fluids. Preliminary in vitro study demonstrates anti-inflammatory effects of strontium for human monocytes cultured in contact with calcium phosphates.

Graphical abstract: Structural characterization of sol–gel derived Sr-substituted calcium phosphates with anti-osteoporotic and anti-inflammatory properties

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Publication details

The article was received on 14 Mar 2008, accepted on 23 May 2008 and first published on 30 Jun 2008


Article type: Paper
DOI: 10.1039/B804140G
Citation: J. Mater. Chem., 2008,18, 3593-3600
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    Structural characterization of sol–gel derived Sr-substituted calcium phosphates with anti-osteoporotic and anti-inflammatory properties

    G. Renaudin, P. Laquerrière, Y. Filinchuk, E. Jallot and J. M. Nedelec, J. Mater. Chem., 2008, 18, 3593
    DOI: 10.1039/B804140G

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