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Issue 23, 2008
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Nanostructured porous hollow ellipsoidal capsules of hydroxyapatite and calcium silicate: preparation and application in drug delivery

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Abstract

We have successfully prepared for the first time hydroxyapatite (HAp) and calcium silicate (CaSiO3) nanostructured porous hollow ellipsoidal capsules which are constructed by nanoplate networks using the inorganic CaCO3 template. CaCO3 ellipsoids are synthesized via the reaction between Ca(CH3COO)2 and NaHCO3 in water and ethylene glycol mixed solvent at room temperature and they are used as the Ca2+ source and cores. Then a PO43 or SiO32 source is added to react with CaCO3 to form a HAp or CaSiO3 shell on the surface of CaCO3 ellipsoids. Dilute acetic acid is used to remove remaining CaCO3 cores. The size and shape of the HAp and CaSiO3 hollow capsules are determined by those of the cores. The thickness of the capsule shell can be controlled by adjusting the concentration of PO43 or SiO32 source. A number of PO43 sources such as dilute H3PO4, Na3PO4 and Na2HPO4 can be used to form HAp hollow capsules with similar morphologies. The drug loading and release behavior of HAp hollow capsules is also investigated. A typical anti-inflammatory drug, ibuprofen, is used for drug loading. The result indicates that HAp hollow capsules have a high specific surface area and high storage capacity, and favorable drug release behavior.

Graphical abstract: Nanostructured porous hollow ellipsoidal capsules of hydroxyapatite and calcium silicate: preparation and application in drug delivery

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Publication details

The article was received on 09 Jan 2008, accepted on 14 Mar 2008 and first published on 08 Apr 2008


Article type: Paper
DOI: 10.1039/B800389K
Citation: J. Mater. Chem., 2008,18, 2722-2727
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    Nanostructured porous hollow ellipsoidal capsules of hydroxyapatite and calcium silicate: preparation and application in drug delivery

    M. Ma, Y. Zhu, L. Li and S. Cao, J. Mater. Chem., 2008, 18, 2722
    DOI: 10.1039/B800389K

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