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Issue 21, 2008
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Fabrication of micropatterned ZnO/SiO2 core/shell nanorod arrays on a nanocrystalline diamond film and their application to DNA hybridization detection

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Abstract

Micropatterned ZnO/SiO2 core/shell nanorod arrays are successfully fabricated on nanocrystalline diamond (NCD) film surfaces, and their performance as a fluorescence signal enhancing platform for DNA hybridization detection is also investigated. The fabrication process, from oriented ZnO nanorod deposition, amine silanation, and attachment of a biofunctional cross-linking molecule to the covalent immobilization of probe oligonucleotides, is defined. X-Ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) are used to characterize ZnO/SiO2 core/shell nanorods. The sequence complementary and stability of the DNA-modified surface are demonstrated in hybridization experiments. The use of ZnO/SiO2 nanorod arrays not only greatly enhances the fluorescence signal collected but also decreases the nonspecific adsorption effect of ZnO nanomaterials after carrying out the hybridization reaction.

Graphical abstract: Fabrication of micropatterned ZnO/SiO2 core/shell nanorod arrays on a nanocrystalline diamond film and their application to DNA hybridization detection

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Publication details

The article was received on 04 Jan 2008, accepted on 12 Mar 2008 and first published on 31 Mar 2008


Article type: Paper
DOI: 10.1039/B800029H
Citation: J. Mater. Chem., 2008,18, 2459-2465
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    Fabrication of micropatterned ZnO/SiO2 core/shell nanorod arrays on a nanocrystalline diamond film and their application to DNA hybridization detection

    J. Zhao, L. Wu and J. Zhi, J. Mater. Chem., 2008, 18, 2459
    DOI: 10.1039/B800029H

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