Protein-passivated Fe3O4 nanoparticles: low toxicity and rapid heating for thermal therapy

Bappaditya Samanta; Haoheng Yan; Nicholas O. Fischer; Jing Shi; D. Joseph Jerry; Vincent M. Rotello

doi:10.1039/B718745A

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Journal of Materials Chemistry

Issue 11, 2008

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Protein-passivated Fe₃O₄ nanoparticles: low toxicity and rapid heating for thermal therapy

Bappaditya Samanta , Haoheng Yan , Nicholas O. Fischer , Jing Shi , D. Joseph Jerry and Vincent M. Rotello

J. Mater. Chem., 2008, 18, 1204-1208

DOI: 10.1039/B718745A
Received 04 Dec 2007, Accepted 23 Jan 2008
First published on the web 19 Feb 2008

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Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.

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Histogram, TGA and stability assay data of nanoparticles
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Bappaditya Samanta
Haoheng Yan
Nicholas O. Fischer
Jing Shi
D. Joseph Jerry
Vincent M. Rotello

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Journal of Materials Chemistry

Protein-passivated Fe₃O₄ nanoparticles: low toxicity and rapid heating for thermal therapy

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