Polymers for intracellular delivery of nucleic acids

Steven R. Little; Daniel S. Kohane

doi:10.1039/B712930K

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Journal of Materials Chemistry

Issue 8, 2008

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Polymers for intracellular delivery of nucleic acids

Steven R. Little and Daniel S. Kohane

J. Mater. Chem., 2008, 18, 832-841

DOI: 10.1039/B712930K
Received 22 Aug 2007, Accepted 24 Oct 2007
First published on the web 14 Nov 2007

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Effective delivery of nucleic acids requires overcoming cellular barriers that would otherwise hinder transport of payload from the extracellular space to the cytoplasm or nucleus of a target cell, and preventing the degradation of the payload. As with many drug-delivery systems, toxicity is an important issue. Rational design of polymers for this purpose, assisted by high-throughput synthesis and screening methods, has had an enormous impact on the field.

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