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Issue 8, 2008
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Rhodium-catalyzed asymmetric transfer hydrogenation of alkyl and aryl ketones in aqueous media

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Abstract

A novel lipophilic rhodium catalyst was evaluated in the enantioselective transfer hydrogenation of ketones in water using sodium formate as the hydride donor, and in the presence of sodium docecylsulfonate. Alkyl alkyl ketones were reduced in good yields and in moderate to good enantioselectivities, and the reduction of aryl alkyl ketones proceeded with excellent enantioselectivity (up to 97% ee).

Graphical abstract: Rhodium-catalyzed asymmetric transfer hydrogenation of alkyl and aryl ketones in aqueous media

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Publication details

The article was received on 11 Apr 2008, accepted on 30 Jun 2008 and first published on 14 Jul 2008


Article type: Communication
DOI: 10.1039/B806177G
Citation: Green Chem., 2008,10, 832-835
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    Rhodium-catalyzed asymmetric transfer hydrogenation of alkyl and aryl ketones in aqueous media

    K. Ahlford, J. Lind, L. Mäler and H. Adolfsson, Green Chem., 2008, 10, 832
    DOI: 10.1039/B806177G

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