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Issue 4, 2008
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Green chemistry metrics: a comparative evaluation of dimethyl carbonate, methyl iodide, dimethyl sulfate and methanol as methylating agents

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Abstract

The methylating efficiency of dimethyl carbonate (DMC), dimethyl sulfate (DMS), methyl iodide (MeI), and methanol (MeOH) was assessed based on atom economy and mass index. These parameters were calculated for three model reactions: the O-methylation of phenol, the mono-C-methylation of phenylacetonitrile, and the mono-N-methylation of aniline. The analysis was carried out over a total of 33 different procedures selected from the literature. Methanol and, in particular, DMC yielded very favourable mass indexes (in the range 3–6) indicating a significant decrease of the overall flow of materials (reagents, catalysts, solvents, etc.), thereby providing safer greener catalytic reactions with no waste.

Graphical abstract: Green chemistry metrics: a comparative evaluation of dimethyl carbonate, methyl iodide, dimethyl sulfate and methanol as methylating agents

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Publication details

The article was received on 12 Sep 2007, accepted on 22 Jan 2008 and first published on 28 Feb 2008


Article type: Paper
DOI: 10.1039/B713985C
Citation: Green Chem., 2008,10, 457-464
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    Green chemistry metrics: a comparative evaluation of dimethyl carbonate, methyl iodide, dimethyl sulfate and methanol as methylating agents

    M. Selva and A. Perosa, Green Chem., 2008, 10, 457
    DOI: 10.1039/B713985C

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