Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer's disease

Lauren E. Scott; Brent D. G. Page; Brian O. Patrick; Chris Orvig

doi:10.1039/B815404J

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Dalton Transactions

Issue 45, 2008

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Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer's disease

Lauren E. Scott , Brent D. G. Page , Brian O. Patrick and Chris Orvig

Dalton Trans., 2008, 6364-6367

DOI: 10.1039/B815404J
Received 03 Sep 2008, Accepted 12 Sep 2008
First published on the web 06 Oct 2008

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Selective design modifications of specifically substituted 3-hydroxy-4(1H)-pyridinones show possibly advantageous ring freedom while maintaining metal-binding ability and antioxidant capacity, moving toward an efficient potential treatment for Alzheimer's disease.

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Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer's disease

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