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Issue 45, 2008
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Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer's disease

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Abstract

Selective design modifications of specifically substituted 3-hydroxy-4(1H)-pyridinones show possibly advantageous ring freedom while maintaining metal-binding ability and antioxidant capacity, moving toward an efficient potential treatment for Alzheimer's disease.

Graphical abstract: Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer's disease

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Publication details

The article was received on 03 Sep 2008, accepted on 12 Sep 2008 and first published on 06 Oct 2008


Article type: Communication
DOI: 10.1039/B815404J
Citation: Dalton Trans., 2008, 6364-6367
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    Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer's disease

    L. E. Scott, B. D. G. Page, B. O. Patrick and C. Orvig, Dalton Trans., 2008, 6364
    DOI: 10.1039/B815404J

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