Bioactive fragments synergically involved in the design of new generation Pt(II) and Pd(II)-based anticancer compounds

Daniela Pucci; Anna Bellusci; Sergio Bernardini; Rossana Bloise; Alessandra Crispini; Giorgio Federici; Paola Liguori; Maria Fatima Lucas; Nino Russo; Alessandra Valentini

doi:10.1039/B808093C

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Dalton Transactions

Issue 43, 2008

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Bioactive fragments synergically involved in the design of new generation Pt(II) and Pd(II)-based anticancer compounds

Daniela Pucci , Anna Bellusci , Sergio Bernardini , Rossana Bloise , Alessandra Crispini , Giorgio Federici , Paola Liguori , Maria Fatima Lucas , Nino Russo and Alessandra Valentini

Dalton Trans., 2008, 5897-5904

DOI: 10.1039/B808093C
Received 14 May 2008, Accepted 17 Jul 2008
First published on the web 04 Sep 2008

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New Pt(II) and Pd(II) complexes with the metal center coordinated to two different chelating ligands, tropolone (trop) and dihexadecyl-2,2′-bipyridine-4,4′-dicarboxylate bipyridine (bipy), [(bipy)M(trop)][CF₃SO₃], have been synthesized and their biological evaluation has been performed demonstrating a remarkable cytotoxic activity in vitro against the human prostate DU145 and hormone-sensitive LNCaP cells lines. Moreover, for the Pt(II) derivative, the molecular structure has been determined by single-crystal X-ray diffraction and computational analysis on the hydrolysis reaction mechanisms have been performed by density functional theory (DFT) calculations, in order to correlate molecular structure, biological activity and mechanism of action of this new class of complexes based on two different bioactive fragments.

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Dalton Transactions

Bioactive fragments synergically involved in the design of new generation Pt(II) and Pd(II)-based anticancer compounds

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