Bisursodeoxycholate(ethylenediamine)platinum(II): a new autofluorescent compound. Cytotoxic activity and cell cycle analysis in ovarian and hematological cell lines

Martín Pérez-Andrés; Juan J. Benito; Emilio Rodríguez-Fernández; Bruna Corradetti; Daniel Primo; Juan L. Manzano; Alberto Orfao; Julio J. Criado

doi:10.1039/B807965J

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Dalton Transactions

Issue 44, 2008

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Bisursodeoxycholate(ethylenediamine)platinum(II): a new autofluorescent compound. Cytotoxic activity and cell cycle analysis in ovarian and hematological cell lines

Martín Pérez-Andrés , Juan J. Benito , Emilio Rodríguez-Fernández , Bruna Corradetti , Daniel Primo , Juan L. Manzano , Alberto Orfao and Julio J. Criado

Dalton Trans., 2008, 6159-6164

DOI: 10.1039/B807965J
Received 09 May 2008, Accepted 12 Aug 2008
First published on the web 25 Sep 2008

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Abstract
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The present paper describes for the first time an intrinsic fluorescent square-planar platinum(II) complex carrying two ursodeoxycholate ligands ([Pt(UDC)₂(en)], where UDC⁻ = ursodeoxycholate), that emits at room temperature once free in solution. Kinetic studies were carried out in aqueous solution and in the presence of different NaCl concentrations: 4 mM (similar to cytoplasmic concentration) and 150 mM (similar to plasmatic concentration). This novel compound was synthesized from a [PtCl₂(en)] complex and shows increased cytotoxic activity against both resting and cycling HeLa cells, with no toxicity for cell lines derived from neoplastic haematopoietic cells.

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¹H, ¹³C and ¹⁹⁵Pt NMR spectra, Fig. A–E
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Articles By

Martín Pérez-Andrés
Juan J. Benito
Emilio Rodríguez-Fernández
Bruna Corradetti
Daniel Primo
Juan L. Manzano
Alberto Orfao
Julio J. Criado

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Dalton Transactions

Bisursodeoxycholate(ethylenediamine)platinum(II): a new autofluorescent compound. Cytotoxic activity and cell cycle analysis in ovarian and hematological cell lines

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