Ru(III)-based compounds with sulfur donor ligands: synthesis, characterization, electrochemical behaviour and anticancer activity

Lorena Giovagnini; Sergio Sitran; Ignazio Castagliuolo; Paola Brun; Maddalena Corsini; Piero Zanello; Alfonso Zoleo; Annalisa Maniero; Barbara Biondi; Dolores Fregona

doi:10.1039/B806341A

skip RSC | ChemSpider | Feedback

Home > Journals > Dalton Transactions > Ru(iii)-based compounds...

Authors & Referees | Librarians

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Dalton Transactions

Issue 47, 2008

More about this Journal
Editorial Board
Submit an Article

Follow Journal | |

Journal Home | RSC Journals

Paper

Previous Article | Next Article

Ru(III)-based compounds with sulfur donor ligands: synthesis, characterization, electrochemical behaviour and anticancer activity

Lorena Giovagnini , Sergio Sitran , Ignazio Castagliuolo , Paola Brun , Maddalena Corsini , Piero Zanello , Alfonso Zoleo , Annalisa Maniero , Barbara Biondi and Dolores Fregona

Dalton Trans., 2008, 6699-6708

DOI: 10.1039/B806341A
Received 14 Apr 2008, Accepted 28 Jul 2008
First published on the web 14 Oct 2008

Please wait while Download options loads

Request Permissions

Abstract
Cited by
Compounds
Related Content

In recent years, Ru(III) complexes have emerged as a new class of effective anticancer agents against tumors that proved to be resistant to all other chemotherapeutic drugs currently in clinical use. To extend our previous studies on metal complexes containing sulfur-donor ligands, we report here on the synthesis and characterization, by means of several spectroscopic and analytical techniques, some [Ru(RSDT)₃] and [Ru₂(RSDT)₅]Cl complexes with dithiocarbamato ligands derived from methyl/ethyl/tert-butyl esters of sarcosine. Their electrochemical behaviour was also studied by cyclic voltammetry. All the complexes were tested for their cytotoxicity on a panel of human tumor cell lines showing highly significant antitumor activity. The chemical and biological properties of the newly synthesized complexes, were compared with those of [Ru(DMDT)₃] and [Ru₂(DMDT)₅]Cl species (DMDT = N,N-dimethyldithiocarbamate) whose chemical (not biological) characterization has been already reported in literature.

This may take some time to load.

Terms & Conditions|Privacy |Accessibility|ACAP Enabled

Dalton Transactions

Ru(III)-based compounds with sulfur donor ligands: synthesis, characterization, electrochemical behaviour and anticancer activity

Log in (Free Access)

Log in (Subscriber Access)

Supplementary Info

Articles By