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Issue 16, 2008
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Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes

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Abstract

We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.

Graphical abstract: Cellular confocal fluorescence studies and cytotoxic activity of new Zn(ii) bis(thiosemicarbazonato) complexes

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Publication details

The article was received on 18 Feb 2008, accepted on 19 Feb 2008 and first published on 18 Mar 2008


Article type: Communication
DOI: 10.1039/B802806K
Citation: Dalton Trans., 2008,0, 2107-2110
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    Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes

    S. I. Pascu, P. A. Waghorn, T. D. Conry, B. Lin, H. M. Betts, J. R. Dilworth, R. B. Sim, G. C. Churchill, F. I. Aigbirhio and J. E. Warren, Dalton Trans., 2008, 0, 2107
    DOI: 10.1039/B802806K

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