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Issue 23, 2008
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Gadolinium(III) complexes as MRI contrast agents: ligand design and properties of the complexes

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Abstract

Magnetic resonance imaging is a commonly used diagnostic method in medicinal practice as well as in biological and preclinical research. Contrast agents (CAs), which are often applied are mostly based on Gd(III) complexes. In this paper, the ligand types and structures of their complexes on one side and a set of the physico-chemical parameters governing properties of the CAs on the other side are discussed. The solid-state structures of lanthanide(III) complexes of open-chain and macrocyclic ligands and their structural features are compared. Examples of tuning of ligand structures to alter the relaxometric properties of gadolinium(III) complexes as a number of coordinated water molecules, their residence time (exchange rate) or reorientation time of the complexes are given. Influence of the structural changes of the ligands on thermodynamic stability and kinetic inertness/lability of their lanthanide(III) complexes is discussed.

Graphical abstract: Gadolinium(iii) complexes as MRI contrast agents: ligand design and properties of the complexes

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Publication details

The article was received on 21 Dec 2007, accepted on 11 Feb 2008 and first published on 27 Mar 2008


Article type: Perspective
DOI: 10.1039/B719704G
Citation: Dalton Trans., 2008, 3027-3047
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    Gadolinium(III) complexes as MRI contrast agents: ligand design and properties of the complexes

    P. Hermann, J. Kotek, V. Kubíček and I. Lukeš, Dalton Trans., 2008, 3027
    DOI: 10.1039/B719704G

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