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Issue 11, 2008
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Chemopreventive effects of natural dietary compounds on cancer development

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Abstract

Chemoprevention, a relatively new and promising strategy to prevent cancer, is defined as the use of natural dietary compounds and/or synthetic substances to block, inhibit, reverse, or retard the process of carcinogenesis. The chemopreventive effects elicited by these natural dietary compounds are believed to include antioxidative, anti-inflammatory activity, induction of phase II enzymes, apoptosis, and cell cycle arrest. Many mechanisms have been shown to account for the anticarcinogenic actions of natural dietary compounds; attention has recently been focused on intracellular-signaling cascades as common molecular targets for various chemopreventive natural dietary compounds. In this critical review, we will summarize current knowledge on natural dietary compounds that act through the signaling pathways and modulate gene expression to induce detoxifying enzymes, programmed cell death, anti-inflammatory, and anti-proliferative effects, thus providing evidence for these substances in cancer chemopreventive action (128 references).

Graphical abstract: Chemopreventive effects of natural dietary compounds on cancer development

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Publication details

The article was received on 30 Jun 2008 and first published on 24 Sep 2008


Article type: Critical Review
DOI: 10.1039/B801558A
Citation: Chem. Soc. Rev., 2008,37, 2558-2574
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    Chemopreventive effects of natural dietary compounds on cancer development

    M. Pan and C. Ho, Chem. Soc. Rev., 2008, 37, 2558
    DOI: 10.1039/B801558A

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