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Issue 6, 2008
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The oxa-Michael reaction: from recent developments to applications in natural product synthesis

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Abstract

In marked contrast to Michael reactions, oxa-Michael reactions have not been used as standard transformations in organic synthesis until quite recently. This was mainly due to a lack of reactivity and selectivity, although the potential products of such reactions are valuable intermediates. This tutorial review presents recent major advances in the field of oxa-Michael (sometimes called oxo-Michael or oxy-Michael) reactions and applications in the total synthesis of complex natural products.

Graphical abstract: The oxa-Michael reaction: from recent developments to applications in natural product synthesis

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Publication details

The article was received on 09 Mar 2008 and first published on 21 Apr 2008


Article type: Tutorial Review
DOI: 10.1039/B718357G
Citation: Chem. Soc. Rev., 2008,37, 1218-1228
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    The oxa-Michael reaction: from recent developments to applications in natural product synthesis

    C. F. Nising and S. Bräse, Chem. Soc. Rev., 2008, 37, 1218
    DOI: 10.1039/B718357G

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