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Issue 5, 2008
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SERS—a single-molecule and nanoscale tool for bioanalytics

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Surface enhanced Raman scattering (SERS) at extremely high enhancement level turns the weak inelastic scattering effect of photons on vibrational quantum states into a structurally sensitive single-molecule and nanoscale probe. The effect opens up exciting opportunities for applications of vibrational spectroscopy in biology. The concept of SERS can be extended to two-photon excitation by exploiting surface enhanced hyper-Raman scattering (SEHRS). This critical review introduces the physics behind single-molecule SERS and discusses the capabilities of the effect in bioanalytics (100 references).

Graphical abstract: SERS—a single-molecule and nanoscale tool for bioanalytics

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Publication details

The article was received on 13 Mar 2008 and first published on 20 Mar 2008

Article type: Critical Review
DOI: 10.1039/B708459P
Citation: Chem. Soc. Rev., 2008,37, 1052-1060
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    SERS—a single-molecule and nanoscale tool for bioanalytics

    J. Kneipp, H. Kneipp and K. Kneipp, Chem. Soc. Rev., 2008, 37, 1052
    DOI: 10.1039/B708459P

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