Chemical technologies for probing embryonic development

Ilya A. Shestopalov; James K. Chen

doi:10.1039/B703023C

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Chemical Society Reviews

Issue 7, 2008

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Chemical technologies for probing embryonic development

Ilya A. Shestopalov and James K. Chen

Chem. Soc. Rev., 2008, 37, 1294-1307

DOI: 10.1039/B703023C
Received 03 Feb 2008, First published on the web 07 May 2008
This article is part of the collection: The Chemistry-Biology Interface

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Embryogenesis is a remarkable program of cell proliferation, migration, and differentiation that transforms a single fertilized egg into a complex multicellular organism. Understanding this process at the molecular and systems levels will require an interdisciplinary approach, including the concepts and technologies of chemical biology. This tutorial review provides an overview of chemical tools that have been used in developmental biology research, focusing on methods that enable spatiotemporal control of gene function and the visualization of embryonic patterning. Limitations of current approaches and future challenges are also discussed.

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