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Issue 7, 2008
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Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria

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Abstract

Bacteria are capable of “communicating” their local population densities via a process termed quorum sensing (QS). Gram-negative bacteria use N-acylated L-homoserine lactones (AHLs), in conjunction with their cognate LuxR-type receptors, as their primary signalling circuit for QS. In this critical review, we examine AHL signalling in Gram-negative bacteria with a primary focus on the design of non-natural AHLs, their structure-activity relationships, and their application in chemical biological approaches to study QS (72 references).

Graphical abstract: Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria

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Publication details

The article was received on 24 Apr 2008 and first published on 02 Jun 2008


Article type: Critical Review
DOI: 10.1039/B703021P
Citation: Chem. Soc. Rev., 2008,37, 1432-1447
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    Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria

    G. D. Geske, J. C. O’Neill and H. E. Blackwell, Chem. Soc. Rev., 2008, 37, 1432
    DOI: 10.1039/B703021P

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