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Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, USA
E-mail: blackwell@chem.wisc.edu
; Fax: +1 608 265 2534
; Tel: +1 608 262 1503
Chem. Soc. Rev., 2008,37, 1432-1447
DOI:
10.1039/B703021P
Received
24 Apr 2008,
First published online
02 Jun 2008
Bacteria are capable of “communicating” their local population densities via a process termed quorum sensing (QS). Gram-negative bacteria use N-acylated L-homoserinelactones (AHLs), in conjunction with their cognate LuxR-type receptors, as their primary signalling circuit for QS. In this critical review, we examine AHLsignalling in Gram-negative bacteria with a primary focus on the design of non-natural AHLs, their structure-activity relationships, and their application in chemical biological approaches to study QS (72 references).
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