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Issue 7, 2008
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Small molecule inhibition of microbial natural product biosynthesis—an emerging antibiotic strategy

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Abstract

A variety of natural products modulate critical biological processes in the microorganisms that produce them. Thus, inhibition of the corresponding natural product biosynthesis pathways represents a promising avenue to develop novel antibiotics. In this tutorial review, we describe several recent examples of designed small molecule inhibitors of microbial natural product biosynthesis and their use in evaluating this emerging antibiotic strategy.

Graphical abstract: Small molecule inhibition of microbial natural product biosynthesis—an emerging antibiotic strategy

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Publication details

The article was received on 02 Mar 2008 and first published on 21 May 2008


Article type: Tutorial Review
DOI: 10.1039/B702780J
Citation: Chem. Soc. Rev., 2008,37, 1320-1329
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    Small molecule inhibition of microbial natural product biosynthesis—an emerging antibiotic strategy

    J. S. Cisar and D. S. Tan, Chem. Soc. Rev., 2008, 37, 1320
    DOI: 10.1039/B702780J

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