Issue 7, 2008

Small molecule inhibition of microbial natural product biosynthesis—an emerging antibiotic strategy

Abstract

A variety of natural products modulate critical biological processes in the microorganisms that produce them. Thus, inhibition of the corresponding natural product biosynthesis pathways represents a promising avenue to develop novel antibiotics. In this tutorial review, we describe several recent examples of designed small molecule inhibitors of microbial natural product biosynthesis and their use in evaluating this emerging antibiotic strategy.

Graphical abstract: Small molecule inhibition of microbial natural product biosynthesis—an emerging antibiotic strategy

Article information

Article type
Tutorial Review
Submitted
02 Mar 2008
First published
21 May 2008

Chem. Soc. Rev., 2008,37, 1320-1329

Small molecule inhibition of microbial natural product biosynthesis—an emerging antibiotic strategy

J. S. Cisar and D. S. Tan, Chem. Soc. Rev., 2008, 37, 1320 DOI: 10.1039/B702780J

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