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Issue 7, 2008
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The human oxygen sensing machinery and its manipulation

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Abstract

Animals respond to the challenge of limited oxygen availability by a coordinated response that works to increase oxygen supply and minimize tissue damage. The chronic hypoxic response is mediated by the α,β-hypoxia inducible transcription factor (HIF) that enables the expression of a gene array. Because this array includes genes encoding for proteins that regulate processes including red blood cell and blood vessel formation, manipulation of the HIF system has potential for the treatment of ischemic diseases, anaemia and tumours. Hydroxylase enzymes act as oxygen sensors by regulating both the lifetime of HIF-α and its transcriptional activity. This tutorial review aims to provide a non-expert introduction to the HIF field by providing a background to current work, summarising molecular knowledge on the HIF system, and outlining opportunities for therapeutic intervention.

Graphical abstract: The human oxygen sensing machinery and its manipulation

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Publication details

The article was received on 01 Apr 2008 and first published on 27 May 2008


Article type: Tutorial Review
DOI: 10.1039/B701676J
Citation: Chem. Soc. Rev., 2008,37, 1308-1319
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    The human oxygen sensing machinery and its manipulation

    R. Chowdhury, A. Hardy and C. J. Schofield, Chem. Soc. Rev., 2008, 37, 1308
    DOI: 10.1039/B701676J

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