Fluorine in medicinal chemistry

Sophie Purser; Peter R. Moore; Steve Swallow; Véronique Gouverneur

doi:10.1039/B610213C

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Chemical Society Reviews

Issue 2, 2008

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Tutorial Review

Fluorine in medicinal chemistry

Sophie Purser,^a Peter R. Moore,^b Steve Swallow^b and Véronique Gouverneur*^a

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The Chemistry Research Laboratory, 12 Mansfield Road, Oxford, UK
E-mail: veronique.gouverneur@chem.ox.ac.uk ;
Fax: +44 (0) 1865 275644 ;
Tel: +44 (0) 1865 275644

AstraZeneca Discovery Chemistry, Alderley Park, Macclesfield, UK

Chem. Soc. Rev., 2008,37, 320-330

DOI: 10.1039/B610213C
Received 26 Nov 2007, First published online 13 Dec 2007

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Abstract
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It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.

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