Automated oligosaccharide synthesis

Peter H. Seeberger

doi:10.1039/B511197H

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Chemical Society Reviews

Issue 1, 2008

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Automated oligosaccharide synthesis

Peter H. Seeberger

Chem. Soc. Rev., 2008, 37, 19-28

DOI: 10.1039/B511197H
Received 27 Jun 2007, First published on the web 20 Aug 2007

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Peptides and oligonucleotides are prepared by automated synthesizers that can be operated by non-specialists. Carbohydrates have been hard to assemble, but the increasing awareness of the biological importance of this class of complex repeating biopolymers has prompted efforts to accelerate their synthesis. This tutorial review defines the state of the art of automated solid phase oligosaccharide synthesis and identifies areas in need of further innovation. Application of the automated synthesis method to prepare a malaria vaccine candidate is briefly highlighted.

Abstract from Methods in Organic Synthesis 2008

A review, with 24 references, of the state of the art of automated solid phase oligosaccharide synthesis, applications, and areas in need of further innovation.

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Automated oligosaccharide synthesis

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