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Issue 7, 2008
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Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine

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Abstract

Four different screening techniques were used to form cocrystals of carbamazepine containing pharmaceutically acceptable carboxylic acids. Twenty-seven unique solid phases utilizing eighteen carboxylic acid coformers were generated in the screening experiments. Cocrystal formation and stability in water is reported. Phase solubility diagrams and triangular phase diagrams are used to illustrate how saturation of the reactants leads to supersaturation of the cocrystal.

Graphical abstract: Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine

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Publication details

The article was received on 08 Oct 2007, accepted on 21 Feb 2008 and first published on 20 Mar 2008


Article type: Paper
DOI: 10.1039/B715396A
Citation: CrystEngComm, 2008,10, 856-864
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    Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine

    S. L. Childs, N. Rodríguez-Hornedo, L. S. Reddy, A. Jayasankar, C. Maheshwari, L. McCausland, R. Shipplett and B. C. Stahly, CrystEngComm, 2008, 10, 856
    DOI: 10.1039/B715396A

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