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Issue 48, 2008
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6,7-Dimethyllumazine as a potential ligand for selective recognition of adenine opposite an abasic site in DNA duplexes

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Abstract

6,7-Dimethyllumazine more selectively binds to adenine (A) base opposite the abasic site in DNA duplexes (5′-TCC AG[X with combining low line] GCA AC-3′/3′-AGG TC[N with combining low line] CGT TG-5′, [X with combining low line] = AP site (Spacer C3), [N with combining low line] = A, T, C and G) than the other three nucleobases with a dissociation constant Kd of ca. 1.0 μM; substituted methyl groups enhance the binding affinity to A and the selectivity for A over T, compared to the parent molecule, lumazine.

Graphical abstract: 6,7-Dimethyllumazine as a potential ligand for selective recognition of adenine opposite an abasic site in DNA duplexes

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Publication details

The article was received on 26 Sep 2008, accepted on 20 Oct 2008 and first published on 12 Nov 2008


Article type: Communication
DOI: 10.1039/B816876H
Citation: Chem. Commun., 2008,0, 6588-6590
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    6,7-Dimethyllumazine as a potential ligand for selective recognition of adenine opposite an abasic site in DNA duplexes

    Z. Ye, B. Rajendar, D. Qing, S. Nishizawa and N. Teramae, Chem. Commun., 2008, 0, 6588
    DOI: 10.1039/B816876H

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