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Issue 47, 2008
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Highly efficient copper-catalyzed cascade synthesis of quinazoline and quinazolinone derivatives

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Abstract

We have developed a general and highly efficient copper-catalyzed method for synthesis of quinazoline and quinazolinone derivatives, the target products were obtained in good to excellent yields via cascade reactions of amidine hydrochlorides with substituted 2-halobenzaldehydes, 2-halophenylketones, or methyl 2-halobenzoates, and the method is of simple, economical and practical advantages.

Graphical abstract: Highly efficient copper-catalyzed cascade synthesis of quinazoline and quinazolinone derivatives

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Publication details

The article was received on 12 Aug 2008, accepted on 22 Sep 2008 and first published on 24 Oct 2008


Article type: Communication
DOI: 10.1039/B814011A
Citation: Chem. Commun., 2008,0, 6333-6335
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    Highly efficient copper-catalyzed cascade synthesis of quinazoline and quinazolinone derivatives

    C. Huang, Y. Fu, H. Fu, Y. Jiang and Y. Zhao, Chem. Commun., 2008, 0, 6333
    DOI: 10.1039/B814011A

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