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Issue 39, 2008
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Synergistic effects in gene delivery—a structure–activity approach to the optimisation of hybrid dendritic–lipidic transfection agents

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Abstract

Novel gene delivery agents based on combining cholesterol units with spermine-functionalised dendrons exhibit enhanced transfection ability—we report significant synergistic effects in mixed (hybrid) systems which combine aspects of both main classes of synthetic vectors, i.e., cationic polymers and lipids.

Graphical abstract: Synergistic effects in gene delivery—a structure–activity approach to the optimisation of hybrid dendritic–lipidic transfection agents

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Publication details

The article was received on 10 Jul 2008, accepted on 13 Aug 2008 and first published on 03 Sep 2008


Article type: Communication
DOI: 10.1039/B811852C
Citation: Chem. Commun., 2008,0, 4700-4702
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    Synergistic effects in gene delivery—a structure–activity approach to the optimisation of hybrid dendritic–lipidic transfection agents

    S. P. Jones, N. P. Gabrielson, D. W. Pack and D. K. Smith, Chem. Commun., 2008, 0, 4700
    DOI: 10.1039/B811852C

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