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Issue 38, 2008
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Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide

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Abstract

A potent dictyostatindiscodermolide hybrid was designed and synthesised; it showed enhanced cell growth inhibitory activity relative to discodermolide in four human cancer cell lines including the Taxol-resistant NCI/ADR-Res cell line.

Graphical abstract: Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide

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Publication details

The article was received on 10 Jul 2008, accepted on 30 Jul 2008 and first published on 28 Aug 2008


Article type: Communication
DOI: 10.1039/B811575C
Citation: Chem. Commun., 2008,0, 4628-4630
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    Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide

    I. Paterson, G. J. Naylor and A. E. Wright, Chem. Commun., 2008, 0, 4628
    DOI: 10.1039/B811575C

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