Design of a novel molecular beacon: modification of the stem with artificially genetic alphabet

Pinpin Sheng; Zunyi Yang; Youngmi Kim; Yanrong Wu; Weihong Tan; Steven A. Benner

doi:10.1039/B811159F

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Chemical Communications

Issue 41, 2008

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Design of a novel molecular beacon: modification of the stem with artificially genetic alphabet

Pinpin Sheng , Zunyi Yang , Youngmi Kim , Yanrong Wu , Weihong Tan and Steven A. Benner

Chem. Commun., 2008, 5128-5130

DOI: 10.1039/B811159F
Received 07 Jul 2008, Accepted 11 Aug 2008
First published on the web 26 Sep 2008

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Abstract
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A molecular beacon that incorporates components of an artificially expanded genetic information system (AEGIS) in its stem is shown not to be opened by unwanted stem invasion by adventitious standard DNA; this should improve the “darkness” of the beacon in real-world applications.

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Pinpin Sheng
Zunyi Yang
Youngmi Kim
Yanrong Wu
Weihong Tan
Steven A. Benner

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Chemical Communications

Design of a novel molecular beacon: modification of the stem with artificially genetic alphabet

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