Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence

Craig P. Montgomery; Elizabeth J. New; David Parker; Robert D. Peacock

doi:10.1039/B810978H

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Chemical Communications

Issue 36, 2008

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Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence

Craig P. Montgomery , Elizabeth J. New , David Parker and Robert D. Peacock

Chem. Commun., 2008, 4261-4263

DOI: 10.1039/B810978H
Received 27 Jun 2008, Accepted 15 Jul 2008
First published on the web 10 Sep 2008

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Abstract
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The helicity of the (SSS)-Δ enantiomer of a terbium and europium(III) complex is inverted on reversible binding to ‘drug site II’ of serum albumin, signalled by a switch in its circularly polarised emission; no such behaviour occurs with the (RRR)-Λ complexes, thereby defining a unique chiroptical probe of albumin binding.

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Selected details of CPL spectra for enantiomeric complexes;relaxivity titrations for Gd complexes as a function of protein;effect of added warfarin and dansylsarcosine on observedrelaxivities for enantiomeric complexes
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Chemical Communications

Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence

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