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Issue 42, 2008
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Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging

Ute Neugebauer,a  Yann Pellegrin,a  Marc Devocelle,c  Robert J. Forster,ab  William Signac,d  Niamh Morand  and  Tia E. Keyes*ab 
Author affiliations

* Corresponding authors

a The Biomedical Diagnostics Institute, Dublin City University, Dublin, Ireland
E-mail: Tia.keyes@dcu.ie

b The School of Chemical Sciences, National Centre for Sensor Research, Dublin City University, Dublin, Ireland

c Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin

d Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin

Abstract

Two novel polyarginine labelled ruthenium polypyridyl dyes are reported, one conjugated to five, (Ru–Ahx–R5), and one to eight arginine residues, (Ru–Ahx–R8); both complexes exhibit long-lived, intense, and oxygen-sensitive luminescence; (Ru–R8) is passively, efficiently and very rapidly transported across the cell membrane into the cytoplasm without requirement for its permeablisation.

Graphical abstract: Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging

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Publication details

The article was received on 18 Jun 2008, accepted on 13 Aug 2008 and first published on 12 Sep 2008


Article type: Communication
DOI: 10.1039/B810403D
Citation: Chem. Commun., 2008,0, 5307-5309
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    Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging

    U. Neugebauer, Y. Pellegrin, M. Devocelle, R. J. Forster, W. Signac, N. Moran and T. E. Keyes, Chem. Commun., 2008, 0, 5307
    DOI: 10.1039/B810403D

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