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Issue 42, 2008
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Dendrimer design using CuI-catalyzed alkyne–azide “click-chemistry”

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The chemoselective [3+2] cycloaddition of an azide on to an alkyne, catalyzed by Cu1, has become known as “click-chemistry”. The ease with which this reaction can be carried out and the formation of pure product without the need for further purification, offer a tremendous potential in developing monodisperse 1,4-disubstituted 1,2,3-triazole heterocycle based macromolecules of a diverse nature. The versatility of this approach in designing dendrimers or functionalizing them at the periphery with desired molecules has rekindled hopes in developing nanomaterials, at scales that can accelerate their entry into industrial usage.

Graphical abstract: Dendrimer design using CuI-catalyzed alkyne–azide “click-chemistry”

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Publication details

The article was received on 11 Jun 2008, accepted on 10 Jul 2008 and first published on 17 Sep 2008

Article type: Feature Article
DOI: 10.1039/B809870K
Citation: Chem. Commun., 2008, 5267-5276
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    Dendrimer design using CuI-catalyzed alkyne–azide “click-chemistry”

    G. Franc and A. Kakkar, Chem. Commun., 2008, 5267
    DOI: 10.1039/B809870K

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