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Issue 34, 2008
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Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N8-citryl-spermidine and its N1-(3,4-dihydroxybenzoyl) derivative

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Abstract

The AsbB enzyme, which is involved in the biosynthesis of the virulence-conferring siderophorepetrobactin in Bacillus anthracis, is shown to catalyze efficient ATP-dependent condensation of spermidine, but not N1-(3,4-dihydroxbenzoyl)-spermidine, with N8-citryl-spermidine or N1-(3,4-dihydroxbenzoyl)-N8-citryl-spermidine, suggesting that N1-(3,4-dihydroxbenzoyl)-spermidine is very unlikely to be a significant intermediate in petrobactinbiosynthesis, contrary to previous suggestions.

Graphical abstract: Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N8-citryl-spermidine and its N1-(3,4-dihydroxybenzoyl) derivative

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Publication details

The article was received on 03 Jun 2008, accepted on 23 Jul 2008 and first published on 31 Jul 2008


Article type: Communication
DOI: 10.1039/B809353A
Citation: Chem. Commun., 2008, 4034-4036
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    Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N8-citryl-spermidine and its N1-(3,4-dihydroxybenzoyl) derivative

    D. Oves-Costales, N. Kadi, M. J. Fogg, L. Song, K. S. Wilson and G. L. Challis, Chem. Commun., 2008, 4034
    DOI: 10.1039/B809353A

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