Toward the discovery of potent inhibitors of botulinum neurotoxin A: development of a robust LC MS based assay operational from low to subnanomolar enzyme concentrations

Kateřina Čapková; Mark S. Hixon; Laura A. McAllister; Kim D. Janda

doi:10.1039/B808305C

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Chemical Communications

Issue 30, 2008

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Toward the discovery of potent inhibitors of botulinum neurotoxin A: development of a robust LC MS based assay operational from low to subnanomolar enzyme concentrations

Kateřina Čapková , Mark S. Hixon , Laura A. McAllister and Kim D. Janda

Chem. Commun., 2008, 3525-3527

DOI: 10.1039/B808305C
Received 16 May 2008, Accepted 18 Jun 2008
First published on the web 03 Jul 2008

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Abstract
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The development of a sensitive, yet reliable assay for the analysis of botulinum neurotoxin A (BoNT/A) inhibitors is described; using this assay a new protease inhibitor was characterized and found to be one of the most potent inhibitors reported to date.

Abstract from Mass Spectrometry Bulletin 2009

Biochemical, LC/MS, Toxicology.

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Chemical Communications

Toward the discovery of potent inhibitors of botulinum neurotoxin A: development of a robust LC MS based assay operational from low to subnanomolar enzyme concentrations

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