Selective synthesis of double temperature-sensitive polymer–peptide conjugates

Florentina Stoica; Cameron Alexander; Nicola Tirelli; Aline F. Miller; Alberto Saiani

doi:10.1039/B806782A

Selective synthesis of double temperature-sensitive polymer–peptide conjugates

Florentina Stoica,^a Cameron Alexander,^b Nicola Tirelli,^c Aline F. Miller^a and Alberto Saiani*^d

Author affiliations

* Corresponding authors

^a School of Chemical Engineering and Analytical Science, University of Manchester, Manchester, UK

^b School of Pharmacy, University of Nottingham, Nottingham, UK

^c School of Pharmacy, University of Manchester, Manchester, UK

^d School of Materials, University of Manchester, Manchester, UK
E-mail: a.saiani@manchester.ac.uk
Fax: +44 161 306 3586
Tel: +44 161 3065981

Abstract

A novel synthetic route has been developed to couple selectively a modified octa-peptide, that is able to gel at low temperature, to the prototypical thermoresponsive polymer poly(N-isopropylacrylamide) to give a bioconjugate that exhibits double thermoresponsiveness.

Supplementary files

Publication details

The article was received on 22 Apr 2008, accepted on 16 May 2008 and first published on 16 Jul 2008

Article type: Communication

DOI: 10.1039/B806782A

Citation: Chem. Commun., 2008, 4433-4435

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Selective synthesis of double temperature-sensitive polymer–peptide conjugates

F. Stoica, C. Alexander, N. Tirelli, A. F. Miller and A. Saiani, Chem. Commun., 2008, 4433
DOI: 10.1039/B806782A
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Florentina Stoica
Cameron Alexander
Nicola Tirelli
Aline F. Miller
Alberto Saiani

Chemical Communications

Selective synthesis of double temperature-sensitive polymer–peptide conjugates

Abstract

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Selective synthesis of double temperature-sensitive polymer–peptide conjugates

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