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Issue 35, 2008
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Towards understanding phosphonoacetaldehyde hydrolase: an alternative mechanism involving proton transfer that triggers P–C bond cleavage

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Abstract

The theoretical QM/MM study of the reaction catalysed by phosphonoacetaldehyde hydrolase indicates a possible alternative mechanism of the P–C bond cleavage: as opposed to the mechanism proposed earlier and that involved formation of a covalently bound intermediate (Schiff-base), in the new mechanism, the bond breaking process is facilitated by proton transfer from catalytic lysine residue to the substrate.

Graphical abstract: Towards understanding phosphonoacetaldehyde hydrolase: an alternative mechanism involving proton transfer that triggers P–C bond cleavage

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Publication details

The article was received on 15 Apr 2008, accepted on 27 May 2008 and first published on 15 Jul 2008


Article type: Communication
DOI: 10.1039/B806280C
Citation: Chem. Commun., 2008,0, 4162-4164
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    Towards understanding phosphonoacetaldehyde hydrolase: an alternative mechanism involving proton transfer that triggers P–C bond cleavage

    B. Szefczyk, Chem. Commun., 2008, 0, 4162
    DOI: 10.1039/B806280C

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