G-quadruplex recognition by bis-indole carboxamides

Jyotirmayee Dash; Pravin S. Shirude; Shankar Balasubramanian

doi:10.1039/B806042H

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Chemical Communications

Issue 26, 2008

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G-quadruplex recognition by bis-indole carboxamides

Jyotirmayee Dash , Pravin S. Shirude and Shankar Balasubramanian

Chem. Commun., 2008, 3055-3057

DOI: 10.1039/B806042H
Received 09 Apr 2008, Accepted 29 Apr 2008
First published on the web 05 Jun 2008

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Abstract
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Herein we report the de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.

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Experimental procedure for FRET, CD and NMR data of indole amides
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Chemical Communications

G-quadruplex recognition by bis-indole carboxamides

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