Reversible siRNA–polymer conjugates by RAFT polymerization

Karina L. Heredia; Thi H. Nguyen; Chien-Wen Chang; Volga Bulmus; Thomas P. Davis; Heather D. Maynard

doi:10.1039/B804812F

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Chemical Communications

Issue 28, 2008

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Reversible siRNA–polymer conjugates by RAFT polymerization

Karina L. Heredia , Thi H. Nguyen , Chien-Wen Chang , Volga Bulmus , Thomas P. Davis and Heather D. Maynard

Chem. Commun., 2008, 3245-3247

DOI: 10.1039/B804812F
Received 20 Mar 2008, Accepted 13 May 2008
First published on the web 06 Jun 2008

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A straightforward synthetic method to prepare pyridyl disulfide end functionalized poly(PEG acrylate) by RAFT polymerization for efficient and reversible conjugation to siRNA is described.

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Karina L. Heredia
Thi H. Nguyen
Chien-Wen Chang
Volga Bulmus
Thomas P. Davis
Heather D. Maynard

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Chemical Communications

Reversible siRNA–polymer conjugates by RAFT polymerization

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