Tuneable pseudorotaxane formation between a biotin–avidin bioconjugate and CBPQT4+

Stuart T. Caldwell; Graeme Cooke; Alan Cooper; Margaret Nutley; Gouher Rabani; Vincent Rotello; Brian O. Smith; Patrice Woisel

doi:10.1039/B803856B

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Tuneable pseudorotaxane formation between a biotin–avidin bioconjugate and CBPQT⁴⁺†

Stuart T. Caldwell,^a Graeme Cooke,*^a Alan Cooper,^a Margaret Nutley,^a Gouher Rabani,^a Vincent Rotello,^b Brian O. Smith^c and Patrice Woisel^d

Author affiliations

* Corresponding authors

^a Glasgow Centre for Physical Organic Chemistry, WestCHEM, Department of Chemistry, Joseph Black Building, University of Glasgow, Glasgow, UK
E-mail: graemec@chem.gla.ac.uk

^b Department of Chemistry, University of Massachusetts at Amherst, Amherst, USA

^c IBLS, University of Glasgow, Glasgow, UK

^d Laboratoire de Chimie Organique et Macromoléculaire, UMR 8009, Université des Sciences et Technologies de Lille, Villeneuve d’Ascq, France

Abstract

A biotinylated 1,5-dialkoxynaphthalene derivative has been shown to have the ability to bind strongly to avidin and thus act as an artificial binding site for cyclobis(paraquat-p-phenylene) thereby facilitating the formation of a tuneable pseudorotaxane-based bioconjugate.

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Supplementary files

Synthesis of 2, NMR and ITC data PDF (598K)

Additions and corrections

Correction HTM (3K)

Article information

DOI: https://doi.org/10.1039/B803856B
Article type: Communication
Submitted: 05 Mar 2008
Accepted: 15 Apr 2008
First published: 08 May 2008

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Chem. Commun., 2008, 2650-2652

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Tuneable pseudorotaxane formation between a biotin–avidin bioconjugate and CBPQT⁴⁺

S. T. Caldwell, G. Cooke, A. Cooper, M. Nutley, G. Rabani, V. Rotello, B. O. Smith and P. Woisel, Chem. Commun., 2008, 2650 DOI: 10.1039/B803856B

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