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Issue 29, 2008
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Synthesis and characterization of a smart contrast agent sensitive to calcium

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Abstract

A novel first-generation Ca2+ sensitive contrast agent, Gd-DOPTRA has been synthesized and characterized. The agent shows ∼100% relaxivity enhancement upon addition of Ca2+. The agent is selective and sensitive to Ca2+ also in the presence of Mg2+ and Zn2+. The relaxivity studies carried out in physiological fluids prove the prospects of the agent for in vivo measurements.

Graphical abstract: Synthesis and characterization of a smart contrast agent sensitive to calcium

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Publication details

The article was received on 04 Feb 2008, accepted on 25 Apr 2008 and first published on 04 Jun 2008


Article type: Communication
DOI: 10.1039/B801975D
Citation: Chem. Commun., 2008,0, 3444-3446
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    Synthesis and characterization of a smart contrast agent sensitive to calcium

    K. Dhingra, M. E. Maier, M. Beyerlein, G. Angelovski and N. K. Logothetis, Chem. Commun., 2008, 0, 3444
    DOI: 10.1039/B801975D

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