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Issue 14, 2008
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A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid

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Abstract

Herein we report radical trapping experiments that support the formation of an acyl radical as the active species from the oxidation of isoniazid; these data provide insight into the mechanism of hydrazide oxidation.

Graphical abstract: A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid

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Publication details

The article was received on 19 Dec 2007, accepted on 25 Jan 2008 and first published on 08 Feb 2008


Article type: Communication
DOI: 10.1039/B719570B
Citation: Chem. Commun., 2008,0, 1695-1697
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    A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid

    R. I. J. Amos, B. S. Gourlay, C. H. Schiesser, J. A. Smith and B. F. Yates, Chem. Commun., 2008, 0, 1695
    DOI: 10.1039/B719570B

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