Issue 14, 2008
From the journal:

Chemical Communications

A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid†‡

Ruth I. J. Amos,a   Brendon S. Gourlay,a   Carl H. Schiesser,cd   Jason A. Smith*ab  and  Brian F. Yatesa  

* Corresponding authors

a School of Chemistry, University of Tasmania, Private Bag 75, Hobart, Australia
E-mail: Jason.Smith@utas.edu.au
Fax: 03 6226 2858
Tel: 03 6226 2182

b Chemistry Department, Texas A&M University, PO Box 300012, College Station, Texas, USA

c School of Chemistry, The University of Melbourne, Victoria 3010, Australia

d Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010, Australia

Abstract

Herein we report radical trapping experiments that support the formation of an acyl radical as the active species from the oxidation of isoniazid; these data provide insight into the mechanism of hydrazide oxidation.

Graphical abstract: A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid

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Article information

DOI
https://doi.org/10.1039/B719570B
Article type
Communication
Submitted
19 Dec 2007
Accepted
25 Jan 2008
First published
08 Feb 2008

Chem. Commun., 2008, 1695-1697

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A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid

R. I. J. Amos, B. S. Gourlay, C. H. Schiesser, J. A. Smith and B. F. Yates, Chem. Commun., 2008, 1695 DOI: 10.1039/B719570B

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