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Issue 16, 2008
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Chemoenzymatic synthesis of prodigiosin analogues—exploring the substrate specificity of PigC

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Abstract

Analogues of prodigiosin, a tripyrrolic pigment produced by Serratia species with potent immunosuppressive and anticancer activities, have been produced by feeding synthetic analogues of the normal precursor MBC to mutants of Serratia sp. ATCC 39006 or to engineered strains of Escherichia coli; in this way it has been shown that the prodigiosin synthesising enzyme, PigC, has a relaxed substrate-specificity.

Graphical abstract: Chemoenzymatic synthesis of prodigiosin analogues—exploring the substrate specificity of PigC

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Publication details

The article was received on 14 Dec 2007, accepted on 15 Jan 2008 and first published on 05 Feb 2008


Article type: Communication
DOI: 10.1039/B719353J
Citation: Chem. Commun., 2008,0, 1862-1864
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    Chemoenzymatic synthesis of prodigiosin analogues—exploring the substrate specificity of PigC

    S. R. Chawrai, N. R. Williamson, G. P. C. Salmond and F. J. Leeper, Chem. Commun., 2008, 0, 1862
    DOI: 10.1039/B719353J

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