Protein scaffold of a designed metalloenzyme enhances the chemoselectivity in sulfoxidation of thioanisole

Jun-Long Zhang; Dewain K. Garner; Lei Liang; Qian Chen; Yi Lu

doi:10.1039/B718915J

Protein scaffold of a designed metalloenzyme enhances the chemoselectivity in sulfoxidation of thioanisole

Jun-Long Zhang,^a Dewain K. Garner,^a Lei Liang,^a Qian Chen^a and Yi Lu*^a

* Corresponding authors

^a Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
E-mail: yi-lu@uiuc.edu
Fax: +1-217-333-2685
Tel: +1-217-333-2619

Abstract

We demonstrate that incorporation of MnSalen into a protein scaffold enhances the chemoselectivity in sulfoxidation of thioanisole and find that both the polarity and hydrogen bonding of the protein scaffold play an important role in tuning the chemoselectivity.

Supplementary files

Publication details

The article was received on 07 Dec 2007, accepted on 04 Jan 2008 and first published on 04 Feb 2008

Article type: Communication

DOI: 10.1039/B718915J

Citation: Chem. Commun., 2008,0, 1665-1667

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Protein scaffold of a designed metalloenzyme enhances the chemoselectivity in sulfoxidation of thioanisole

J. Zhang, D. K. Garner, L. Liang, Q. Chen and Y. Lu, Chem. Commun., 2008, 0, 1665
DOI: 10.1039/B718915J
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Chemical Communications

Protein scaffold of a designed metalloenzyme enhances the chemoselectivity in sulfoxidation of thioanisole

Abstract

Supplementary files

Publication details

Protein scaffold of a designed metalloenzyme enhances the chemoselectivity in sulfoxidation of thioanisole

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